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Clinically, PCOS patients exhibit reduced gut microbial -diversity, an elevated Bacteroidetes-to-Firmicutes ratio, and decreased abundance of beneficial bacteria such as Akkermansia muciniphila
194 In addition to these direct effects, GLP-1R agonists also contribute to cardiovascular risk reduction through systemic metabolic regulation
The TRIUMPH-3 population had severe obesity and established cardiovascular disease, so that readout matters because it speaks to a higher-risk cardiometabolic cohort
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